Biased mutations and microsatellite variation
نویسندگان
چکیده
منابع مشابه
Biased mutations and microsatellite variation.
Mutation bias is one of the forces that may constrain the variation at microsatellite loci. Here, we study the dynamics of population statistics and the genetic distance between two populations under multiple stepwise mutations with linear bias and random drift. Expressions are derived for these statistics as functions of time, as well as at mutation-drift equilibrium. Applying these expression...
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Microsatellites have been widely used as tools for population studies. However, inference about population processes relies on the specification of mutation parameters that are largely unknown and likely to differ across loci. Here, we use data on somatic mutations to investigate the mutation process at 14 tetranucleotide repeats and carry out an advanced multilocus analysis of different demogr...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 1997
ISSN: 0737-4038,1537-1719
DOI: 10.1093/oxfordjournals.molbev.a025835